Article
The Effect of Afatinib Treatment in Non-small Cell Lung Cancer Cells.
Anticancer research - 1 Jul 2017
Pancewicz-Wojtkiewicz Joanna, Bernatowicz Pawel Leszek
Abstract excerpt
BACKGROUND: Non-small cell lung cancer (NSCLC) is a very aggressive and histologically heterogeneous type of lung cancer. The main problem in the treatment of NSCLC is chemoresistance and metastasis. Compared to other malignant tumors, many molecular mechanisms are dysfunctional in NSCLC. Epidermal growth factor receptor (EGFR) is one of the most frequently mutated genes in NSCLC. MATERIALS AND METHODS: We...
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