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Article

Mutually exclusive recurrent KRAS and MAP2K1 mutations in Rosai-Dorfman disease.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Oct 2017

Garces Sofia, Medeiros L Jeffrey, Patel Keyur P, Li Shaoying, Pina-Oviedo Sergio, Li Jingyi, Garces Juan C, Khoury Joseph D, Yin C Cameron

Abstract excerpt

Rosai-Dorfman disease is a histiocytic disorder with a poorly defined pathogenesis. Recent molecular studies have revealed recurrent mutations involving genes in the MAPK/ERK pathway in Langerhans cell histiocytosis and Erdheim-Chester disease. However, cases of Rosai-Dorfman disease have rarely been assessed. We performed next-generation sequencing to assess 134 genes on 21 cases of Rosai-Dorfman disease,...

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Identifiers

PMID: 28664935
DOI: 10.1038/modpathol.2017.55
PMCID: PMC5837474

Genes

KRAS
ARAF
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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