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Article

Skewed X-chromosome inactivation and XIST locus methylation levels do not contribute to the lower prevalence of Parkinson's disease in females.

Neurobiology of aging - 1 Sept 2017

Sharma Amit, Kaut Oliver, Pavlova Anna, Fröhlich Holger, Ahmad Ashar, Schmitt Ina, El-Maarri Osman, Oldenburg Johannes, Wüllner Ullrich

Abstract excerpt

Parkinson's disease (PD) is a degenerative disorder of the nervous system and the cause of the majority of sporadic cases is unknown. Females are relatively protected from PD as compared with males and linkage studies suggested a PD susceptibility locus on the X chromosome. To determine a putative association of skewed X-chromosome inactivation (XCI) and PD, we examined XCI patterns using a human androgen...

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Identifiers

PMID: 28663000
DOI: 10.1016/j.neurobiolaging.2017.05.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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