Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In vivo modeling of human liver for pharmacological study using humanized mouse.

Expert opinion on drug metabolism & toxicology - 1 Nov 2009

Yoshizato Katsutoshi, Tateno Chise

Abstract excerpt

The liver occupies a central place in the treatment of the substances taken into the body. If we could devise an in vivo or in vitro model that perfectly mimics the naturally-created human (h) liver, the work required for making effective and safe medicines would become easier and could be undertaken more cost effectively than it is currently. Considering the advantages of in vivo modeling over in vitro modeling...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Transport, Active
Share to Genetic Vectors
Share to Hepatocytes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Mutant Chimeric Proteins

Share to Species Specificity

Share to Viruses

Source

Identifiers

PMID: 19715443
DOI: 10.1517/17425250903216664

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In vivo modeling of human liver for pharmacological study using humanized mouse.PMID 19715443Read ↗

Mice with Liver Composed of Human Hepatocytes as an Animal Model for Drug TestingSemantic proximity Read ↗

A comparison between genetically humanized and chimeric liver humanized mouse models for studies in drug metabolism and toxicitySemantic proximity Read ↗

Are Humanized Mouse Models Useful for Basic Research of Hepatocarcinogenesis through Chronic Hepatitis B Virus Infection?Semantic proximity Read ↗

Investigation of Biotransformation Pathways in a Chimeric Mouse with a Humanized LiverSemantic proximity Read ↗

Application of Chimeric Mice with Humanized Liver for Study of Human-Specific Drug MetabolismSemantic proximity Read ↗

P450-Humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and ToxicitySemantic proximity Read ↗

New horizons for studying human hepatotropic infectionsSemantic proximity Read ↗

Mouse models for the study of HCV infection and virus–host interactionsSemantic proximity Read ↗

Human Three-Dimensional Hepatic Models: Cell Type Variety and Corresponding ApplicationsSemantic proximity Read ↗

Modeling drug-induced liver injury: current status and future prospectsSemantic proximity Read ↗

A Chimeric Humanized Mouse Model by Engrafting the Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cell for the Chronic Hepatitis B Virus InfectionSemantic proximity Read ↗

Human-Mouse Convergence in Metabolic Dysfunction-Associated Steatotic Liver Disease: Mouse Model Selection and Non-Invasive Diagnostic StrategiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.