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Young adult survivors of childhood acute lymphoblastic leukemia show evidence of chronic inflammation and cellular aging.

Cancer - 1 Nov 2017

Ariffin Hany, Azanan Mohamad Shafiq, Abd Ghafar Sayyidatul Syahirah, Oh Lixian, Lau Kee Hie, Thirunavakarasu Tharshanadhevasheri, Sedan Atiqah, Ibrahim Kamariah, Chan Adelyne, Chin Tong Foh, Liew Fong Fong, Jeyamogan Shareni, Rosli Erda Syerena, Baharudin Rashidah, Yap Tsiao Yi, Skinner Roderick, Lum Su Han, Hainaut Pierre

Abstract excerpt

BACKGROUND: Large epidemiologic studies have reported the premature onset of age-related conditions, such as ischemic heart disease and diabetes mellitus, in childhood cancer survivors, decades earlier than in their peers. The authors investigated whether young adult survivors of childhood acute lymphoblastic leukemia (ALL) have a biologic phenotype of cellular ageing and chronic inflammation. METHODS: Plasma...

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PMID: 28654149
DOI: 10.1002/cncr.30857

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