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Article

RNA editing by the host ADAR system affects the molecular evolution of the Zika virus

15 May 2017

Abstract excerpt

Zika virus (ZIKV) is a mosquito-transmitted flavivirus, linked to microcephaly and fetal death in humans. Here, we investigate whether host-mediated RNA editing of adenosines (ADAR) plays a role in the molecular evolution of ZIKV. Using complete coding sequences for the ZIKV polyprotein, we show that potential ADAR substitutions are underrepresented at the ADAR-resistant GA dinucleotides of both the positive and...

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PMID: 28649357
DOI: 10.1002/ece3.3033

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