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Structural Biology and the Design of New Therapeutics: From HIV and Cancer to Mycobacterial Infections

23 Jun 2017

Abstract excerpt

Interest in applications of protein crystallography to medicine was evident, as the first high-resolution structures emerged in the 50s and 60s. In Cambridge, Max Perutz and John Kendrew sought to understand mutations in sickle cell and other genetic diseases related to hemoglobin, while in Oxford, the group of Dorothy Hodgkin became interested in long-lasting zinc-insulin crystals for treatment of diabetes and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28648615
DOI: 10.1016/j.jmb.2017.06.014

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