Article
Aberrant intestinal microbiota due to IL-1 receptor antagonist deficiency promotes IL-17- and TLR4-dependent arthritis.
Microbiome - 23 Jun 2017
Rogier Rebecca, Ederveen Thomas H A, Boekhorst Jos, Wopereis Harm, Scher Jose U, Manasson Julia, Frambach Sanne J C M, Knol Jan, Garssen Johan, van der Kraan Peter M, Koenders Marije I, van den Berg Wim B, van Hijum Sacha A F T, Abdollahi-Roodsaz Shahla
Abstract excerpt
BACKGROUND: Perturbation of commensal intestinal microbiota has been associated with several autoimmune diseases. Mice deficient in interleukin-1 receptor antagonist (Il1rn -/- mice) spontaneously develop autoimmune arthritis and are susceptible to other autoimmune diseases such as psoriasis, diabetes, and encephalomyelitis; however, the mechanisms of increased susceptibility to these autoimmune phenotypes are...
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