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Article

Notch1 maintains dormancy of olfactory horizontal basal cells, a reserve neural stem cell.

Proceedings of the National Academy of Sciences of the United States of America - 11 Jul 2017

Herrick Daniel B, Lin Brian, Peterson Jesse, Schnittke Nikolai, Schwob James E

Abstract excerpt

The remarkable capacity of the adult olfactory epithelium (OE) to regenerate fully both neurosensory and nonneuronal cell types after severe epithelial injury depends on life-long persistence of two stem cell populations: the horizontal basal cells (HBCs), which are quiescent and held in reserve, and mitotically active globose basal cells. It has recently been demonstrated that down-regulation of the ΔN form of...

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Identifiers

PMID: 28637720
DOI: 10.1073/pnas.1701333114
PMCID: PMC5514720

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