Article
Cytochrome P-450-mediated O-demethylation of two ellipticine derivatives. Differential effect of the murine Ah locus phenotype.
Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2000
Roy M, Monsarrat B, Cros S, Lecointe P, Rivalle C, Bisagni E
Abstract excerpt
The O-demethylation of two antitumor drugs (9-methoxyellipticine and a 1-polyalkylamino-substituted analog) was studied by incubation with liver microsomes from rats and mice. The former drug underwent a cytochrome P1-450-independent biotransformation in mice, as shown by an indiscriminate response from individuals genetically responsive or nonresponsive to induction by 3-methylcholanthrene. On the other hand,...
Topics
- Alkaloids
- Animals
- Aroclors
- Aryl Hydrocarbon Hydroxylases
- Chlorodiphenyl (54% Chlorine)
- Chromatography, High Pressure Liquid
- Cytochrome P-450 Enzyme System
- Dealkylation
- Ellipticines
- Enzyme Induction