Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FBW7-Dependent Mcl-1 Degradation Mediates the Anticancer Effect of Hsp90 Inhibitors.

Molecular cancer therapeutics - 1 Sept 2017

Tong Jingshan, Tan Shuai, Nikolovska-Coleska Zaneta, Yu Jian, Zou Fangdong, Zhang Lin

Abstract excerpt

Heat shock protein 90 (Hsp90) is widely overexpressed in cancer cells and necessary for maintenance of malignant phenotypes. Hsp90 inhibition induces tumor cell death through degradation of its client oncoproteins and has shown promises in preclinical studies. However, the mechanism by which Hsp90 inhibitors kill tumor cells is not well-understood. Biomarkers associated with differential sensitivity and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to F-Box-WD Repeat-Containing Protein 7
Share to Glycogen Synthase Kinase 3 beta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heterografts

Share to HSP90 Heat-Shock Proteins

Share to Myeloid Cell Leukemia Sequence 1 Protein

Share to Proteasome Endopeptidase Complex

Share to Proteolysis

Share to RNA, Small Interfering

Source

Open in PubMed Open full text

Identifiers

PMID: 28619760
DOI: 10.1158/1535-7163.MCT-17-0032
PMCID: PMC5587378

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FBW7-Dependent Mcl-1 Degradation Mediates the Anticancer Effect of Hsp90 Inhibitors.PMID 28619760Read ↗

Mcl-1 Ubiquitination and DestructionSemantic proximity Read ↗

Mcl-1 inhibition overcomes intrinsic and acquired regorafenib resistance in colorectal cancer.Semantic proximity Read ↗

Targeting FBW7 as a Strategy to Overcome Resistance to Targeted Therapy in Non–Small Cell Lung CancerSemantic proximity Read ↗

FBXW7 attenuates tumor drug resistance and enhances the efficacy of immunotherapySemantic proximity Read ↗

Tumor suppression by the Fbw7 ubiquitin ligase: mechanisms and opportunities.Semantic proximity Read ↗

A novel C-terminal heat shock protein 90 inhibitor that overcomes STAT3-Wnt-β-catenin signaling-mediated drug resistance and adverse effectsSemantic proximity Read ↗

Cabozantinib selectively induces proteasomal degradation of p53 somatic mutant Y220C and impedes tumor growth.Semantic proximity Read ↗

Diptoindonesin G is a middle domain HSP90 modulator for cancer treatment.Semantic proximity Read ↗

Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment.Semantic proximity Read ↗

Co-targeting HSP90 alpha and CDK7 overcomes resistance against HSP90 inhibitors in BCR-ABL1+ leukemia cells.Semantic proximity Read ↗

Hsp90 inhibition by WK88-1 potently suppresses the growth of gefitinib-resistant H1975 cells harboring the T790M mutation in EGFR.Semantic proximity Read ↗

Heat shock protein 90Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.