Article
Early- and late-onset preeclampsia and the DNA methylation of circadian clock and clock-controlled genes in placental and newborn tissues.
Chronobiology international - 1 Jan 2017
van den Berg C B, Chaves I, Herzog E M, Willemsen S P, van der Horst G T J, Steegers-Theunissen R P M
Abstract excerpt
The placenta is important in providing a healthy environment for the fetus and plays a central role in the pathophysiology of preeclampsia (PE). Fetal and placental developments are influenced by epigenetic programming. There is some evidence that PE is controlled to an altered circadian homeostasis. In a nested case-control study embedded in the Rotterdam Periconceptional Cohort, we obtained placental tissue,...
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