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Article

The association between germline BRCA2 variants and sensitivity to platinum-based chemotherapy among men with metastatic prostate cancer.

Cancer - 15 Sept 2017

Pomerantz Mark M, Spisák Sandor, Jia Li, Cronin Angel M, Csabai Istvan, Ledet Elisa, Sartor A Oliver, Rainville Irene, O'Connor Edward P, Herbert Zachary T, Szállási Zoltan, Oh William K, Kantoff Philip W, Garber Judy E, Schrag Deborah, Kibel Adam S, Freedman Matthew L

Abstract excerpt

BACKGROUND: Breast cancer 2 (BRCA2)-associated breast and ovarian cancers are sensitive to platinum-based chemotherapy. It is unknown whether BRCA2-associated prostate cancer responds favorably to such treatment. METHODS: A retrospective analysis of a single-institution cohort of men with castration-resistant, metastatic prostate cancer was performed to determine the association between carrier status of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28608931
DOI: 10.1002/cncr.30808
PMCID: PMC5802871

Genes

BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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