Targeting the Wnt Pathway and Cancer Stem Cells with Anti-progastrin Humanized Antibodies as a Potential Treatment for K-RAS-Mutated Colorectal Cancer.

doi:10.1158/1078-0432.CCR-17-0533

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Article

Targeting the Wnt Pathway and Cancer Stem Cells with Anti-progastrin Humanized Antibodies as a Potential Treatment for K-RAS-Mutated Colorectal Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2017

Prieur Alexandre, Cappellini Monica, Habif Guillaume, Lefranc Marie-Paule, Mazard Thibault, Morency Eric, Pascussi Jean-Marc, Flacelière Maud, Cahuzac Nathalie, Vire Bérengère, Dubuc Benjamin, Durochat Amandine, Liaud Pierre, Ollier Jérémy, Pfeiffer Caroline, Poupeau Sophie, Saywell Véronique, Planque Chris, Assenat Eric, Bibeau Frédéric, Bourgaux Jean-François, Pujol Pascal, Sézeur Alain, Ychou Marc, Joubert Dominique

Abstract excerpt

Purpose: Patients with metastatic colorectal cancer suffer from disease relapse mainly due to cancer stem cells (CSC). Interestingly, they have an increased level of blood progastrin, a tumor-promoting peptide essential for the self-renewal of colon CSCs, which is also a direct β-catenin/TCF4 target gene. In this study, we aimed to develop a novel targeted therapy to neutralize secreted progastrin to inhibit Wnt...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28600477
DOI: 10.1158/1078-0432.CCR-17-0533

Genes

TCF4

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