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Article

Identification of a rare LAMB4 variant associated with familial diverticulitis through exome sequencing.

Human molecular genetics - 15 Aug 2017

Coble Joel L, Sheldon Kathryn E, Yue Feng, Salameh Tarik J, Harris Leonard R, Deiling Sue, Ruggiero Francesca M, Eshelman Melanie A, Yochum Gregory S, Koltun Walter A, Gerhard Glenn S, Broach James R

Abstract excerpt

Diverticulitis is a chronic disease of the colon in which diverticuli, or outpouching through the colonic wall, become inflamed. Although recent observations suggest that genetic factors may play a significant role in diverticulitis, few genes have yet been implicated in disease pathogenesis and familial cases are uncommon. Here, we report results of whole exome sequencing performed on members from a single...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28595269
DOI: 10.1093/hmg/ddx204
PMCID: PMC6251658

Genes

LAMB4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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