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Article

A mutation in PTPN11 may drive leukemic transformation in a case of essential thrombocythemia.

Leukemia & lymphoma - 1 Jan 2018

Guo Belinda B, Liang James, Allcock Richard J N, Mirzai Bob, Augustson Bradley, Howman Rebecca, Fuller Kathryn A, Erber Wendy N

Abstract excerpt

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Topics

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Share to Acute Disease
Share to Aged, 80 and over
Share to Cell Transformation, Neoplastic
Share to Disease Progression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myeloid

Share to Mutation

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 11

Share to Thrombocythemia, Essential

Source

Identifiers

PMID: 28587547
DOI: 10.1080/10428194.2017.1324162

Genes

PTPN11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

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Research trail→

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A mutation in PTPN11 may drive leukemic transformation in a case of essential thrombocythemia.PMID 28587547Read ↗

Acute myeloid leukemia in an adult Noonan syndrome patient with PTPN11 mutation.Semantic proximity Read ↗

Identification of putative noncanonical driver mutations in patients with essential thrombocythemia.Semantic proximity Read ↗

Transient myeloproliferative disorder in an infant with PTPN11 mutation.Semantic proximity Read ↗

NF-E2 mutation as a novel cause for inherited thrombocytopenia.Semantic proximity Read ↗

Sharing of a PTPN11 mutation by myelodysplastic bone marrow and a mature plasmacytoid dendritic cell proliferation provides evidence for their common myelomonocytic origin.Semantic proximity Read ↗

Familial Essential Thrombocytemia : 6 cases from a mono-institutional series.Semantic proximity Read ↗

Acute myeloid leukemia with inversion 16 and a novel PTPN11 mutation: A case report with literature review.Semantic proximity Read ↗

Non-driver gene mutation analysis in a large cohort of polycythemia vera and essential thrombocythemia.Semantic proximity Read ↗

PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase.Semantic proximity Read ↗

The clinical features and prognostic implications of PTPN11 mutation in adult patients with acute myeloid leukemia in China.Semantic proximity Read ↗

Novel CUX1 missense mutation in association with 7q- at leukemic transformation of MPN.Semantic proximity Read ↗

Hereditary thrombocytosis not as innocent as thought? Development into acute leukemia and myelofibrosis.Semantic proximity Read ↗

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