Article
Effective treatment of SIVcpz-induced immunodeficiency in a captive western chimpanzee.
Retrovirology - 2 Jun 2017
Barbian Hannah J, Jackson-Jewett Raven, Brown Corrine S, Bibollet-Ruche Frederic, Learn Gerald H, Decker Timothy, Kreider Edward F, Li Yingying, Denny Thomas N, Sharp Paul M, Shaw George M, Lifson Jeffrey, Acosta Edward P, Saag Michael S, Bar Katharine J, Hahn Beatrice H
Abstract excerpt
BACKGROUND: Simian immunodeficiency virus of chimpanzees (SIVcpz), the progenitor of human immunodeficiency virus type 1 (HIV-1), is associated with increased mortality and AIDS-like immunopathology in wild-living chimpanzees (Pan troglodytes). Surprisingly, however, similar findings have not been reported for chimpanzees experimentally infected with SIVcpz in captivity, raising questions about the intrinsic...
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