Article
A Synonymous Mutation at Bovine Alpha Vitronectin Domain of Integrin Host Receptor (ITGAV) Gene Effect the Susceptibility of Foot-and-Mouth Disease in Crossbred Cattle.
Advances in experimental medicine and biology - 1 Jan 2000
Singh Rani, Alex Rani, Singh Umesh, Kumar Sushil, Sengar Gyanendra Singh, Raja T V, Alyethodi R R, Kumar Ashish, Deb Rajib
Abstract excerpt
Integrins are one of the major biologically active proteins responsible for Foot-and-mouth disease virus (FMDV)- host interaction. Out of various heterodimeric integrins discovered, αVβ6 heterodimer serves as the chief receptor for FMDV host tropism. Earlier studies reported that, SNPs at beta 6 subunit (ITGB6) were associated with the occurrence of the diseases in cattle. In this study we report the association...
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