Article
Influence of mucinous and necrotic tissue in colorectal cancer samples on KRAS mutation analysis.
Pathology, research and practice - 1 Jun 2017
Büttner Juliane, Lehmann Annika, Klauschen Frederick, Hummel Michael, Lenze Dido, Dietel Manfred, Jöhrens Korinna
Abstract excerpt
Evaluation of the RAS mutation status is necessary for patients with advanced colorectal cancer to predict the response to anti-EGFR therapy. In routine diagnostics, FFPE tissue samples are tested by sequencing (amplicon-based NGS and Sanger) to obtain the RAS status of the patient. Samples that are collected after chemotherapy occasionally contain necrotic tissue. Furthermore, colorectal cancer tissue sometimes...
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