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Article

Evidence for double-strand break mediated mitochondrial DNA replication in Saccharomyces cerevisiae.

Nucleic acids research - 27 Jul 2017

Prasai Kanchanjunga, Robinson Lucy C, Scott Rona S, Tatchell Kelly, Harrison Lynn

Abstract excerpt

The mechanism of mitochondrial DNA (mtDNA) replication in Saccharomyces cerevisiae is controversial. Evidence exists for double-strand break (DSB) mediated recombination-dependent replication at mitochondrial replication origin ori5 in hypersuppressive ρ- cells. However, it is not clear if this replication mode operates in ρ+ cells. To understand this, we targeted bacterial Ku (bKu), a DSB binding protein, to the...

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Identifiers

PMID: 28549155
DOI: 10.1093/nar/gkx443
PMCID: PMC5569933

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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