Article
High throughput resistance profiling of Plasmodium falciparum infections based on custom dual indexing and Illumina next generation sequencing-technology.
Scientific reports - 25 May 2017
Nag Sidsel, Dalgaard Marlene D, Kofoed Poul-Erik, Ursing Johan, Crespo Marina, Andersen Lee O'Brien, Aarestrup Frank Møller, Lund Ole, Alifrangis Michael
Abstract excerpt
Genetic polymorphisms in P. falciparum can be used to indicate the parasite's susceptibility to antimalarial drugs as well as its geographical origin. Both of these factors are key to monitoring development and spread of antimalarial drug resistance. In this study, we combine multiplex PCR, custom designed dual indexing and Miseq sequencing for high throughput SNP-profiling of 457 malaria infections from...
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