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Article

Concordance of bioactive vs. total immunoreactive serum leptin levels in children with severe early onset obesity.

PloS one - 1 Jan 2017

Stanik Juraj, Kratzsch Jürgen, Landgraf Kathrin, Scheuermann Kathrin, Spielau Ulrike, Gausche Ruth, Gasperikova Daniela, Kiess Wieland, Körner Antje

Abstract excerpt

CONTEXT: Leptin secreted from adipose tissue signals peripheral energy status to the brain. Monogenic leptin deficiency results in severe early onset obesity with hyperphagia. Recently, a similar phenotype of inactivating leptin mutations but with preserved immunoreactivity and hence normal circulating immunoreactive leptin has been reported. OBJECTIVE: We aimed to evaluate the proportion of bioactive leptin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28542631
DOI: 10.1371/journal.pone.0178107
PMCID: PMC5441582

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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