Article
Immunoglobulin M gene association with autoantibody reactivity and type 1 diabetes.
Immunogenetics - 1 Jul 2017
Rolim Inês, Duarte Nádia, Barata Gabriela, Costa João, Gardete-Correia Luís, Boavida José, Duarte Rui, Raposo João, Peerally Zulmira, Catarino Manuela, Penha-Gonçalves Carlos
Abstract excerpt
Several lines of evidence show that autoimmune responses evolving in type 1 diabetes (T1D) patients include the generation of multi-reactive autoantibody (AutoAb) repertoires, but their role in T1D pathogenesis remains elusive. We tested the hypothesis that variants at the immunoglobulin heavy chain (IGH) locus are genetic determinants of AutoAbs against pancreatic antigens and contribute to T1D susceptibility....
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