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Article

A Trans-acting Factor May Modify Age at Onset in Familial Amyloid Polyneuropathy ATTRV30M in Portugal.

Molecular neurobiology - 1 May 2018

Alves-Ferreira Miguel, Coelho Teresa, Santos Diana, Sequeiros Jorge, Alonso Isabel, Sousa Alda, Lemos Carolina

Abstract excerpt

Although all familial amyloid polyneuropathy (FAP) ATTRV30M patients carry the same causative mutation, early (<40) and late-onset forms (≥50 years) of FAP may coexist in the same family. However, this variability in age at onset is still unexplained. To identify modifiers closely linked to the TTR locus that may in part be associated with age at onset of FAP ATTRV30M, in particular in a group of very early-onset...

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Source

Identifiers

PMID: 28527106
DOI: 10.1007/s12035-017-0593-4

Genes

FAP
TTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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