Article
Acquired resistance to macrolides in Pseudomonas aeruginosa from cystic fibrosis patients.
The European respiratory journal - 1 May 2017
Mustafa Muhammad-Hariri, Khandekar Shaunak, Tunney Michael M, Elborn J Stuart, Kahl Barbara C, Denis Olivier, Plésiat Patrick, Traore Hamidou, Tulkens Paul M, Vanderbist Francis, Van Bambeke Françoise
Abstract excerpt
Cystic fibrosis (CF) patients receive chronic treatment with macrolides for their antivirulence and anti-inflammatory properties. We, however, previously showed that Pseudomonas aeruginosa, considered as naturally resistant to macrolides, becomes susceptible when tested in a eukaryotic medium rather than a conventional broth.We therefore looked for specific macrolide resistance determinants in 333 CF isolates...
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