Article
The association of single-nucleotide polymorphisms in the oxytocin receptor and G protein-coupled receptor kinase 6 (GRK6) genes with oxytocin dosing requirements and labor outcomes.
American journal of obstetrics and gynecology - 1 Sept 2017
Grotegut Chad A, Ngan Emily, Garrett Melanie E, Miranda Marie Lynn, Ashley-Koch Allison E, Swamy Geeta K
Abstract excerpt
BACKGROUND: Oxytocin is a potent uterotonic agent that is widely used for induction and augmentation of labor. Oxytocin has a narrow therapeutic index and the optimal dosing for any individual woman varies widely. OBJECTIVE: The objective of this study was to determine whether genetic variation in the oxytocin receptor (OXTR) or in the gene encoding G protein-coupled receptor kinase 6 (GRK6), which regulates...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.