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Safety evaluation of an oat grain alkaloid gramine by genotoxicity assays.

Drug and chemical toxicology - 1 Apr 2018

Pathak Manash Pratim, Policegoudra Rudragoud S, Goyary Danswrang, Das Aparoop, Mandal Santa, Chakraborti Srijita, Bora Nilutpal Sharma, Islam Johirul, Patowary Pompy, Raju P Srinivas, Chattopadhyay Pronobesh

Abstract excerpt

Gramine is a natural indole alkaloid that has been isolated from different raw plants occurring mainly in Avena sativa, etc. The study was aimed to investigate the possible in vitro antioxidant, in vitro mutagenic, in vitro antimutagenic, and in vivo genotoxic activity of gramine using ferric reducing ability of plasma (FRAP) assay, Metal chelating, Ames bacterial reverse mutation test, and the mouse bone marrow...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28523965
DOI: 10.1080/01480545.2017.1322605

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