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Article

Fatty Acid Oxidation in Zebrafish Adipose Tissue Is Promoted by 1α,25(OH)2D3.

Cell reports - 16 May 2017

Peng Xuyan, Shang Guohui, Wang Wenqing, Chen Xiaowen, Lou Qiyong, Zhai Gang, Li Dongliang, Du Zhenyu, Ye Yali, Jin Xia, He Jiangyan, Zhang Yi, Yin Zhan

Abstract excerpt

1α,25(OH)2D3 (vitamin D3) is crucial for mineral homeostasis in mammals, but the precise effects of 1α,25(OH)2D3 in adipose tissue remain to be clarified in vivo. The initial 25-hydroxylation is catalyzed by liver microsomal cytochrome P450 2R1 (CYP2R1), which is conserved in vertebrates. To probe the physiological function(s) of 1α,25(OH)2D3 in teleosts, we generated two independent cyp2r1-deficient zebrafish...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28514663
DOI: 10.1016/j.celrep.2017.04.066

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