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Article

N-acetylcysteine potentiates diclofenac toxicity in Saccharomyces cerevisiae: stronger potentiation in ABC transporter mutant strains.

Drug and chemical toxicology - 1 Jan 2018

Al-Attrache Houssein, Chamieh Hala, Hamzé Monzer, Morel Isabelle, Taha Samir, Abdel-Razzak Ziad

Abstract excerpt

Diclofenac (DCF) adverse reactions involve diverse mechanisms in different models. We recently demonstrated that DCF-induced toxicity in HepaRG decreases as they express DCF-metabolizing enzymes. DCF metabolism promotes toxicity in Saccharomyces cerevisiae expressing heterologous cytochromes-P450. N-Acetylcysteine (NAC) is used to treat diverse medical conditions due to its multiple properties (antioxidant, metal...

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Identifiers

PMID: 28504001
DOI: 10.1080/01480545.2017.1320404

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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