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Article

HIV Reprograms Human Airway Basal Stem/Progenitor Cells to Acquire a Tissue-Destructive Phenotype.

Cell reports - 9 May 2017

Chung Nancy P Y, Ou Xuemei, Khan K M Faisal, Salit Jacqueline, Kaner Robert J, Crystal Ronald G

Abstract excerpt

While highly active anti-retroviral therapy has dramatically improved the survival of HIV-infected individuals, there is an increased risk for other co-morbidities, such as COPD, manifesting as emphysema. Given that emphysema originates around the airways and that human airway basal cells (BCs) are adult airway stem/progenitor cells, we hypothesized that HIV reprograms BCs to a distinct phenotype that contributes...

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Identifiers

PMID: 28494859
DOI: 10.1016/j.celrep.2017.04.026
PMCID: PMC5521803

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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