Article
Exogenous alpha 1-antitrypsin down-regulates SERPINA1 expression.
PloS one - 1 Jan 2017
Karadagi Ahmad, Johansson Helene, Zemack Helen, Salipalli Sandeep, Mörk Lisa-Mari, Kannisto Kristina, Jorns Carl, Gramignoli Roberto, Strom Stephen, Stokkeland Knut, Ericzon Bo-Göran, Jonigk Danny, Janciauskiene Sabina, Nowak Greg, Ellis Ewa C S
Abstract excerpt
The main goal of the therapy with purified human plasma alpha1-antitrypsin (A1AT) is to increase A1AT levels and to prevent lungs from elastolytic activity in patients with PiZZ (Glu342Lys) A1AT deficiency-related emphysema. Potential hepatic gains of this therapy are unknown. Herein, we investigated the effect of A1AT therapy on SERPINA1 (gene encoding A1AT) expression. The expression of SERPINA1 was determined...
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