Article
Whole-Genome Sequencing Reveals the Contribution of Long-Term Carriers in Staphylococcus aureus Outbreak Investigation.
Journal of clinical microbiology - 1 Jul 2017
Gordon N C, Pichon B, Golubchik T, Wilson D J, Paul J, Blanc D S, Cole K, Collins J, Cortes N, Cubbon M, Gould F K, Jenks P J, Llewelyn M, Nash J Q, Orendi J M, Paranthaman K, Price J R, Senn L, Thomas H L, Wyllie S, Crook D W, Peto T E A, Walker A S, Kearns A M
Abstract excerpt
Whole-genome sequencing (WGS) makes it possible to determine the relatedness of bacterial isolates at a high resolution, thereby helping to characterize outbreaks. However, for Staphylococcus aureus, the accumulation of within-host diversity during carriage might limit the interpretation of sequencing data. In this study, we hypothesized the converse, namely, that within-host diversity can in fact be exploited to...
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