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Article

Sequence variations of the EGR4 gene in Korean men with spermatogenesis impairment.

BMC medical genetics - 2 May 2017

Sung Se Ra, Song Seung Hun, Kang Kyung Min, Park Ji Eun, Nam Yeo Jung, Shin Yun-Jeong, Cha Dong Hyun, Seo Ju Tae, Yoon Tae Ki, Shim Sung Han

Abstract excerpt

BACKGROUND: Egr4 is expressed in primary and secondary spermatocytes in adult mouse testes and has a crucial role in regulating germ cell maturation. The functional loss of Egr4 blocks spermatogenesis, significantly reducing the number of spermatozoa that are produced. In this study, we examined whether EGR4 variants are present in Korean men with impaired spermatogenesis. METHODS: A total 170 Korean men with...

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Identifiers

PMID: 28464846
DOI: 10.1186/s12881-017-0408-5
PMCID: PMC5414287

Genes

EGR4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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