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Article

N-myc downstream regulated gene 1(NDRG1) promotes the stem-like properties of lung cancer cells through stabilized c-Myc.

Cancer letters - 10 Aug 2017

Wang Yongfang, Zhou You, Tao Feng, Chai Shoujie, Xu Xia, Yang Ying, Yang Yiming, Xu Haiyan, Wang Kai

Abstract excerpt

Tumor-initiating cells (TICs) play an important role in tumorigenesis and development for many various tissue origin cancers including non-small cell lung cancer (NSCLC). However, the mechanism to maintain TICs in NSCLC is still largely unknown. Here, we evaluated differences of mRNA expression between parental and oncosphere cells that enriched TICs. We found that N-myc downstream regulated gene 1(NDRG1) was...

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Source

Identifiers

PMID: 28456659
DOI: 10.1016/j.canlet.2017.04.031

Genes

CDK2
KLF4
MYC
SOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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