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KRAS mutation testing on all non-malignant diagnosis of pancreatic endoscopic ultrasound-guided fine-needle aspiration biopsies improves diagnostic accuracy.

Pathology - 1 Jun 2017

Trisolini Elena, Armellini Elia, Paganotti Alessia, Veggiani Claudia, Bozzola Cristina, Frattini Milo, Pizio Corinna, Mancuso Giuseppe, Andorno Silvano, Boldorini Renzo

Abstract excerpt

Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is the procedure of choice for the cytologic diagnosis of pancreatic masses. The specificity of EUS-FNA approaches 100%, but the sensitivity is still low, and the high rate of indeterminate (atypical and suspicious) and false-negative results needs improvement. KRAS gene is frequently mutated in pancreatic ductal adenocarcinoma (PDAC) (up to 90%), and...

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Identifiers

PMID: 28450086
DOI: 10.1016/j.pathol.2016.12.348

Genes

KRAS

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