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Article

An In Vitro Organ Culture Model of the Murine Intervertebral Disc.

Journal of visualized experiments : JoVE - 11 Apr 2017

Liu Jennifer W, Lin Kevin H, Weber Christian, Bhalla Sameer, Kelso Sean, Wang Kaixi, Tang Simon Y

Abstract excerpt

Intervertebral disc (IVD) degeneration is a significant contributor to low back pain. The IVD is a fibrocartilaginous joint that serves to transmit and dampen loads in the spine. The IVD consists of a proteoglycan-rich nucleus pulposus (NP) and a collagen-rich annulus fibrosis (AF) sandwiched by cartilaginous end-plates. Together with the adjacent vertebrae, the vertebrae-IVD structure forms a functional spine...

Topics

Animals
Cartilage
Cell Differentiation
Extracellular Matrix
Finite Element Analysis
Humans
Intervertebral Disc
Intervertebral Disc Degeneration
Mice
Organ Culture Techniques
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Open in PubMed Open full text

Identifiers

PMID: 28448052
DOI: 10.3791/55437
PMCID: PMC5495460

Genes

IVD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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