Article
Genotype-outcome correlations in pediatric AML: the impact of a monosomal karyotype in trial AML-BFM 2004.
Leukemia - 1 Dec 2017
Rasche M, von Neuhoff C, Dworzak M, Bourquin J-P, Bradtke J, Göhring G, Escherich G, Fleischhack G, Graf N, Gruhn B, Haas O A, Klingebiel T, Kremens B, Lehrnbecher T, von Stackelberg A, Tchinda J, Zemanova Z, Thiede C, von Neuhoff N, Zimmermann M, Creutzig U, Reinhardt D
Abstract excerpt
We conducted a cytogenetic analysis of 642 children with de novo acute myeloid leukemia (AML) treated on the AML-Berlin-Frankfurt-Münster (BFM) 04 protocol to determine the prognostic value of specific chromosomal aberrations including monosomal (MK+), complex (CK+) and hypodiploid (HK+) karyotypes, individually and in combination. Multivariate regression analysis identified in particular MK+ (n=22) as a new...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.