Article
Dismal prognostic value of monosomal karyotype in elderly patients with acute myeloid leukemia: a GOELAMS study of 186 patients with unfavorable cytogenetic abnormalities.
Blood - 21 Jul 2011
Perrot Aurore, Luquet Isabelle, Pigneux Arnaud, Mugneret Francine, Delaunay Jacques, Harousseau Jean-Luc, Barin Carole, Cahn Jean-Yves, Guardiola Philippe, Himberlin Chantal, Recher Christian, Vey Norbert, Lioure Bruno, Ojeda-Uribe Mario, Fegueux Nathalie, Berthou Christian, Randriamalala Edouard, Béné Marie C, Ifrah Norbert, Witz Francis
Abstract excerpt
The prognosis of acute myeloid leukemia (AML) is very poor in elderly patients, especially in those classically defined as having unfavorable cytogenetics. The recent monosomal karyotype (MK) entity, defined as 2 or more autosomal monosomies or combination of 1 monosomy with structural abnormalities, has been reported to be associated with a worse outcome than the traditional complex karyotype (CK). In this...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.