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Article

Roles of the PDZ ‐binding motif of HPV 16 E6 protein in oncogenic transformation of human cervical keratinocytes

25 Apr 2017

Abstract excerpt

The high‐risk human papillomavirus E6 proteins have been shown to interact with and lead to degradation of PDZ ‐domain‐containing proteins through its carboxy‐terminal motif. This PDZ ‐binding motif plays important roles in transformation of cultured cells and carcinogenesis of E6‐transgenic mice. However, its biological effects on the natural host cells have not been elucidated. We have examined its roles in an...

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PMID: 28440909
DOI: 10.1111/cas.13264

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