Article
Unacylated Ghrelin Enhances Satellite Cell Function and Relieves the Dystrophic Phenotype in Duchenne Muscular Dystrophy mdx Model.
Stem cells (Dayton, Ohio) - 1 Jul 2017
Reano Simone, Angelino Elia, Ferrara Michele, Malacarne Valeria, Sustova Hana, Sabry Omar, Agosti Emanuela, Clerici Sara, Ruozi Giulia, Zentilin Lorena, Prodam Flavia, Geuna Stefano, Giacca Mauro, Graziani Andrea, Filigheddu Nicoletta
Abstract excerpt
Muscle regeneration depends on satellite cells (SCs), quiescent precursors that, in consequence of injury or in pathological states such as muscular dystrophies, activate, proliferate, and differentiate to repair the damaged tissue. A subset of SCs undergoes self-renewal, thus preserving the SC pool and its regenerative potential. Unacylated ghrelin (UnAG) is a circulating hormone that protects muscle from...
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