Article
Sputum basophils are increased in eosinophilic asthma compared with non-eosinophilic asthma phenotypes.
Allergy - 1 Oct 2017
Brooks C R, van Dalen C J, Hermans I F, Gibson P G, Simpson J L, Douwes J
Abstract excerpt
Sputum basophil numbers are increased in allergic asthmatics, but it is unclear what role airway basophils play in "TH2-low" asthma phenotypes. Using flow cytometry, we found that basophils were significantly increased in all asthmatics (n=26) compared with healthy controls (n=8) (P=0.007) with highest levels observed in eosinophilic asthma (EA); median 0.22%, IQR 0.11%-0.47%; n=14) compared with non-EA (NEA)...
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