PIK3CA Mutations Contribute to Acquired Cetuximab Resistance in Patients with Metastatic Colorectal Cancer.

doi:10.1158/1078-0432.CCR-16-2738

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Article

PIK3CA Mutations Contribute to Acquired Cetuximab Resistance in Patients with Metastatic Colorectal Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Aug 2017

Xu Jian-Ming, Wang Yan, Wang You-Liang, Wang Yan, Liu Tao, Ni Ming, Li Man-Sheng, Lin Li, Ge Fei-Jiao, Gong Chun, Gu Jun-Yan, Jia Ru, Wang He-Fei, Chen Yu-Ling, Liu Rong-Rui, Zhao Chuan-Hua, Tan Zhao-Li, Jin Yang, Zhu Yun-Ping, Ogino Shuji, Qian Zhi-Rong

Abstract excerpt

Purpose: Mutations in KRAS are considered to be the main drivers of acquired resistance to epidermal growth factor receptor (EGFR) blockade in patients with metastatic colorectal cancer (mCRC). However, the potential role of other genes downstream of the EGFR signaling pathway in conferring acquired resistance has not been extensively investigated.Experimental Design: Using circulating tumor DNA (ctDNA) from...

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PMID: 28424201
DOI: 10.1158/1078-0432.CCR-16-2738
PMCID: PMC5559326

Genes

EGFR
KRAS

Variants

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