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Article

Mechanisms of resistance to anti-epidermal growth factor receptor inhibitors in metastatic colorectal cancer.

World journal of gastroenterology - 28 Jul 2016

Sforza Vincenzo, Martinelli Erika, Ciardiello Fortunato, Gambardella Valentina, Napolitano Stefania, Martini Giulia, Della Corte Carminia, Cardone Claudia, Ferrara Marianna L, Reginelli Alfonso, Liguori Giuseppina, Belli Giulio, Troiani Teresa

Abstract excerpt

The prognosis of patients with metastatic colorectal cancer (mCRC) remain poor despite the impressive improvement of treatments observed over the last 20 years that led to an increase in median overall survival from 6 mo, with the only best supportive care, to approximately 30 mo with the introduction of active chemotherapy drugs and targeted agents. The monoclonal antibodies (moAbs) cetuximab and panitumumab,...

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Identifiers

PMID: 27605871
DOI: 10.3748/wjg.v22.i28.6345
PMCID: PMC4968117

Genes

EGFR
KRAS
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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