Article
Long non-coding RNAs in cutaneous melanoma: clinical perspectives.
Oncotarget - 27 Jun 2017
Hulstaert Eva, Brochez Lieve, Volders Pieter-Jan, Vandesompele Jo, Mestdagh Pieter
Abstract excerpt
Metastatic melanoma of the skin has a high mortality despite the recent introduction of targeted therapy and immunotherapy. Long non-coding RNAs (lncRNAs) are defined as transcripts of more than 200 nucleotides in length that lack protein-coding potential. There is growing evidence that lncRNAs play an important role in gene regulation, including oncogenesis. We present 13 lncRNA genes involved in the...
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