Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Elucidation of the complex metabolic profile of cerebrospinal fluid using an untargeted biochemical profiling assay.

Molecular genetics and metabolism - 1 Jun 2017

Kennedy Adam D, Pappan Kirk L, Donti Taraka R, Evans Anne M, Wulff Jacob E, Miller Luke A D, Reid Sutton V, Sun Qin, Miller Marcus J, Elsea Sarah H

Abstract excerpt

We sought to determine the molecular composition of human cerebrospinal fluid (CSF) and identify the biochemical pathways represented in CSF to understand the potential for untargeted screening of inborn errors of metabolism (IEMs). Biochemical profiles for each sample were obtained using an integrated metabolomics workflow comprised of four chromatographic techniques followed by mass spectrometry. Secondarily,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers
Share to Cerebrospinal Fluid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Child, Preschool

Share to Infant

Share to Mass Spectrometry

Share to Metabolism, Inborn Errors

Share to Metabolome

Share to Metabolomics

Source

Open in PubMed Open full text

Identifiers

PMID: 28412083
DOI: 10.1016/j.ymgme.2017.04.005
PMCID: PMC6200411

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Elucidation of the complex metabolic profile of cerebrospinal fluid using an untargeted biochemical profiling assay.PMID 28412083Read ↗

Multi-platform characterization of the human cerebrospinal fluid metabolome: a comprehensive and quantitative updateSemantic proximity Read ↗

Cerebrospinal fluid metabolomics identifies 19 brain-related phenotype associationsSemantic proximity Read ↗

Cerebrospinal fluid metabolomics identifies 19 brain-related phenotype associations.Semantic proximity Read ↗

Analysis of cerebrospinal fluid metabolites in patients with primary or metastatic central nervous system tumors.Semantic proximity Read ↗

Next‐generation metabolic screening: targeted and untargeted metabolomics for the diagnosis of inborn errors of metabolism in individual patientsSemantic proximity Read ↗

Clinical Validation of Targeted and Untargeted Metabolomics Testing for Genetic Disorders: A 3 Year Comparative Study.Semantic proximity Read ↗

Biochemical phenotyping unravels novel metabolic abnormalities and potential biomarkers associated with treatment of GLUT1 deficiency with ketogenic diet.Semantic proximity Read ↗

Plasma metabolomic profiles enhance precision medicine for volunteers of normal healthSemantic proximity Read ↗

Metabolic Profiling of CSF from People Suffering from Sporadic and LRRK2 Parkinson's Disease: A Pilot Study.Semantic proximity Read ↗

Metabolic profiling of CSF from people suffering from Sporadic and LRRK2 Parkinson’s disease: a pilot study.Semantic proximity Read ↗

Untargeted Plasma Metabolomics Extends the Biomarker Profile of Mitochondrial Neurogastrointestinal EncephalomyopathySemantic proximity Read ↗

Metabolic profiling for biomarker discovery in biochemical geneticsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.