Article
Plasma from patients with anti-glomerular basement membrane disease could recognize microbial peptides.
PloS one - 1 Jan 2017
Li Jian-Nan, Jia Xiaoyu, Wang Yongqiang, Xie Can, Jiang Taijiao, Cui Zhao, Zhao Ming-Hui
Abstract excerpt
Infection has long been suspected as a trigger of autoimmune diseases, and molecular mimicry mechanism was hypothesized in this study. Microbe originated peptides were searched from the Uniprot database based on a previous defined critical amino acid motif within α3129-150, isoleucine137, tryptophan140, glycine142, phenylalanine 143 and phenylalanine 145. 23826 microbial peptides were identified using our...
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