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Article

Landscape of immunogenic tumor antigens in successful immunotherapy of virally induced epithelial cancer

13 Apr 2017

Abstract excerpt

Immunotherapy has clinical activity in certain virally associated cancers. However, the tumor antigens targeted in successful treatments remain poorly defined. We used a personalized immunogenomic approach to elucidate the global landscape of antitumor T cell responses in complete regression of human papillomavirus-associated metastatic cervical cancer after tumor-infiltrating adoptive T cell therapy. Remarkably,...

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PMID: 28408606
DOI: 10.1126/science.aak9510

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