Article
H2A monoubiquitination in Arabidopsis thaliana is generally independent of LHP1 and PRC2 activity.
Genome biology - 12 Apr 2017
Zhou Yue, Romero-Campero Francisco J, Gómez-Zambrano Ángeles, Turck Franziska, Calonje Myriam
Abstract excerpt
BACKGROUND: Polycomb group complexes PRC1 and PRC2 repress gene expression at the chromatin level in eukaryotes. The classic recruitment model of Polycomb group complexes in which PRC2-mediated H3K27 trimethylation recruits PRC1 for H2A monoubiquitination was recently challenged by data showing that PRC1 activity can also recruit PRC2. However, the prevalence of these two mechanisms is unknown, especially in...
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