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Article

Amino acid polymorphisms in the fibronectin-binding repeats of fibronectin-binding protein A affect bond strength and fibronectin conformation.

The Journal of biological chemistry - 26 May 2017

Casillas-Ituarte Nadia N, Cruz Carlos H B, Lins Roberto D, DiBartola Alex C, Howard Jessica, Liang Xiaowen, Höök Magnus, Viana Isabelle F T, Sierra-Hernández M Roxana, Lower Steven K

Abstract excerpt

The Staphylococcus aureus cell surface contains cell wall-anchored proteins such as fibronectin-binding protein A (FnBPA) that bind to host ligands (e.g. fibronectin; Fn) present in the extracellular matrix of tissue or coatings on cardiac implants. Recent clinical studies have found a correlation between cardiovascular infections caused by S. aureus and nonsynonymous SNPs in FnBPA. Atomic force microscopy (AFM),...

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Share to Adhesins, Bacterial
Share to Amino Acid Substitution

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microscopy, Atomic Force

Share to Mutation, Missense

Share to Polymorphism, Single Nucleotide

Share to Repetitive Sequences, Amino Acid

Share to Staphylococcus aureus

Share to Surface Plasmon Resonance

Source

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Identifiers

PMID: 28400484
DOI: 10.1074/jbc.M117.786012
PMCID: PMC5448106

Genes

SPR
AFM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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