Neonatal Inhibition of DNA Methylation Alters Cell Phenotype in Sexually Dimorphic Regions of the Mouse Brain.

doi:10.1210/en.2017-00205

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Neonatal Inhibition of DNA Methylation Alters Cell Phenotype in Sexually Dimorphic Regions of the Mouse Brain.

Endocrinology - 1 Jun 2017

Mosley Morgan, Weathington Jill, Cortes Laura R, Bruggeman Emily, Castillo-Ruiz Alexandra, Xue Bingzhong, Forger Nancy G

Abstract excerpt

Many of the best-studied neural sex differences relate to differences in cell number and are due to the hormonal control of developmental cell death. However, several prominent neural sex differences persist even if cell death is eliminated. We hypothesized that these may reflect cell phenotype "decisions" that depend on epigenetic mechanisms, such as DNA methylation. To test this, we treated newborn mice with...

Topics

Animals
Animals, Newborn
Brain
Cytidine
DNA (Cytosine-5-)-Methyltransferase 1
DNA (Cytosine-5-)-Methyltransferases
DNA Methylation
Down-Regulation
Female
Male
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred C57BL

Neurons

Phenotype

Sex Characteristics

Sex Determination Processes

Time Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 28398586
DOI: 10.1210/en.2017-00205
PMCID: PMC5460944

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neonatal Inhibition of DNA Methylation Alters Cell Phenotype in Sexually Dimorphic Regions of the Mouse Brain.PMID 28398586Read ↗

DNA methylation and demethylation shape sexual differentiation of neurochemical phenotype.Semantic proximity Read ↗

DNA Methylation and Demethylation Underlie the Sex Difference in Estrogen Receptor Alpha in the Arcuate NucleusSemantic proximity Read ↗

Assessment of Epigenetic Contributions to Sexually-Dimorphic Kiss1 Expression in the Anteroventral Periventricular Nucleus of MiceSemantic proximity Read ↗

Sex Differences in the Cerebellum and Frontal Cortex: Roles of Estrogen Receptor Alpha and Sex Chromosome GenesSemantic proximity Read ↗

Inhibition of DNA Methylation in the Developing Rat Brain Disrupts Sexually Dimorphic Neurobehavioral Phenotypes in Adulthood.Semantic proximity Read ↗

Epigenetic Control of Sexual Differentiation of the Bed Nucleus of the Stria TerminalisSemantic proximity Read ↗

Increased apoptosis during neonatal brain development underlies the adult behavioral deficits seen in mice lacking a functional paternally expressed gene 3 (Peg3).Semantic proximity Read ↗

Major sex differences in non-genomic estrogen actions on intracellular signaling in mouse brain in vivo.Semantic proximity Read ↗

A noninvasive genetic/pharmacologic strategy for visualizing cell morphology and clonal relationships in the mouse.Semantic proximity Read ↗

Oestrogen receptor alpha and beta immunoreactive cells in the suprachiasmatic nucleus of mice: distribution, sex differences and regulation by gonadal hormones.Semantic proximity Read ↗

Sex differences in brain developing in the presence or absence of gonadsSemantic proximity Read ↗

Neonatal uterine and vaginal cell proliferation and adenogenesis are independent of estrogen receptor 1 (ESR1) in the mouse.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.